Complete Publication List at PubMed

2024

  1. Kim CY, SK Kannan, VP Badovinac, and TS Griffith. Protocol for inducing monomicrobial sepsis in mice with uropathogenic E.coli. STAR Protoc in press (2024)
  2. Van de Wall S, SA Anthony, RA Langlois, D Zehn, VP Badovinac, and JT Harty. Dynamic landscapes of protective influenza-specific CD8+ lung resident memory T cells revealed by intravital imaging. Immunity in press (2024)
  3. Carey A, K Nguyen, P Kandikonda, V Kruglov, C Bradley, KJV Dahlquist, S Cholensky, W Swanson, VP Badovinac, TS Griffith, and CD Camell. Age-associated accumulation of B cells promotes macrophage inflammation and inhibits lipolysis in adipose tissue during sepsis. Cell Rep 43, 113967 (2024) [PubMed]
  4. Unsinger J, D Osborne, AH Walton, E Han, L Sheets, MB Mazer, KE Remy, TS Griffith, M Rao, VP Badovinac, SC Brackenridge, I Turnbull, PA Efron, LL Moldawer, CC Caldwell and Hotchkiss. Temporal changes in innate and adaptive immunity during sepsis as determined by ELISpot. Shock 62: 255-264 (2024) [PubMed]
  5. Kannan SK*, CY Kim*, M Heidarian, RR Berton, IJ Jensen, TS Griffith*, and VP Badovinac*. Mouse models of sepsis. Curr Protoc 4, e997 (2024) [PubMed]
  6. Hassert M, LL Pewe, R He, M Heidarian, P Phruttiwanichakun, S Van de Wall, MR Mix, AK Salem, VP Badovinac*, and JT Harty*. Regenerating CD8+ lung tissue resident memory T cells after targeted radiation exposure. J Exp Med 221: e20231144 (2024) [PubMed]
  7. Silva EE, SJ Moioffer, M Hassert, RR Berton, MG Smith, S Van de Wall, DK Meyerholz, TS Griffith, JT Harty, and VP Badovinac. Defining parameters that modulate susceptibility and protection to respiratory murine coronavirus MHV1 infection. J Immunol 212: 563-575 (2024) [PubMed]
  8. Barrios EL, MB Mazer, P McGonagill, CB Bergmann, MD Goodman, RW Gould, M Rao, V Polcz, R Davis, D Del Toro, M Dirain, A Dram, L Hale, M Heidarian, CY Kim, TA Kucaba, JP Lanz, A McCray, S Meszaros, S Miles, C Nelson, I Rocha, EE Silva, R Ungaro, A Walton, J Xue, L Zeumer-Spataro, AM Drewry, M Liang, LE Bible, T Loftus, I Turnbull, PA Efron, KE Remy, S Brakenridge, VP Badovinac, TS Griffith, LL Moldawer, RS Hotchkiss and CC Caldwell. Adverse long-term outcomes and an immune suppressed endotype in sepsis patients with reduced interferon-g ELISpot: A multicenter, prospective observational study.  JCI Insight 9: e175785 (2024) [PubMed]

2023

  1. Martin MD, C Skon-Hegg, C Kim, J Xu, TA Kucaba, W Swanson, VP Badovinac, S Shen, MA Ingersoll, and TS Griffith. CD115+ monocytes protect microbially experienced mice against E.coli-induced sepsis. Cell Rep 42: 113345 (2023) [PubMed]
  2. Berton RR, PW McGonagill, IJ Jensen, TK Ybarra, GA Bishop, JT Harty, TS Griffith, and VP Badovinac. Sepsis leads to lasting changes in phenotype and function of naïve CD8 T cells. PLoS Pathog 10: e1011720 (2023) [PubMed]
  3. Silva EE, C Skon-Hegg, VP Badovinac, and TS Griffith.  The calm after the storm: Implications of sepsis immunoparalyses on host immunity.  J Immunol 211: 711-719 (2023) [PubMed]
  4. Heidarian M, IJ Jensen, SK Kannan, LL Pewe, M Hassert, S Park, HH Xue, JT Harty*, and VP Badovinac*.  Sublethal whole-body irradiation induces permanent loss and dysfunction in pathogen-specific circulating memory CD8 T cell populations.  PNAS 120: e2302785120 (2023) [PubMed]
  5. Van de Wall S, S Crooks, SM Varga, VP Badovinac, and JT Harty. Cutting Edge: Influenza-induced CD11alo airway CD103+ tissue resident memory T cells exhibit compromised IFN-g production after in vivo TCR stimulation.  J Immunol 210: 1025-1030 (2023) [PubMed]
  6. Heidarian M, TS Griffith, and VP Badovinac.  Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets.  Front Immunol 14: 1130009 (2023) [PubMed]
  7. Moioffer SJ, RR Berton, PW McGonagill, IJ Jensen, TS Griffith, and VP Badovinac. Inefficient recovery of repeatedly stimulated memory CD8 T cells after polymicrobial sepsis induction leads to changes in memory CD8 T cell pool composition. J Immunol 210:168-179 (2023) [PubMed]

2022

  1. Jensen IJ, MD Martin, SK Tripathy, and VP Badovinac. Novel mouse model of MCMV-induced adaptive NK cells. Immunohorizons 6: 8-15 (2022)[PubMed]
  2. Shan Q, SS Hu, S Zhu, X Chen, VP Badovinac, W Peng, C Zang, and HH Xue. Tcf1 preprograms glycolysis mobilization in central memory CD8 T cells in recall response. Nat Immunol 23: 386-398 (2022)[PubMed]
  3. Berton RR, IJ Jensen, JT Harty, TS Griffith, and VP Badovinac. Inflammation controls susceptibility of immune experienced mice to sepsis. Immunohorizons 6: 825-842 (2022)[PubMed]

2021

  1. Van de Wall S, VP Badovinac, and JT Harty. Influenza-specific lung resident memory CD8+ T cells. Cold Spring Harb Perspect Biol 13: a037978 (2021) [PubMed]
  2. Brate AA, AW Boyden, IJ Jensen, VP Badovinac, and NJ Karandikar. A functionally distinct CXCR3+/IFNg+/IL-10+ subset defines disease-suppresive CNS-specific CD8 T cells. J Immunol 206: 1151-1160 (2021) [PubMed]
  3. Jensen IJ, PW Mc Gonagill, NS Butler, JT Harty, TS Griffith, and VP Badovinac. NK cell-derived IL-10 supports host survival during sepsis. J Immunol 206: 1171-1180 (2021) [PubMed]
  4. Jensen IJ, PW McGonagill, RR Berton, BA Wagner, EE Silva, GR Buettner, TS Griffith, and VP Badovinac. Prolonged ROS production following septic insult. Immunohorizons 5: 477-488 (2021)  [PubMed]
  5. Antony SM*, N Van Braeckel-Budimir*, SJ Moioffer, S van de Wall, Q Shan, R Vijay, R Sompallae, SM Hartwig, IJ Jensen, SM Varga, NS Butler, HH Xue, VP Badovinac*, and JT Harty*. Protective function and durability of mouse lymph node resident memory CD8 T cells. eLife 10: e68662 2021) [PubMed]
  6. Greenfield KG, VP Badovinac, TS Griffith, and KA Knoop. Sepsis, cytokine storms and immunopathology: The divide between neonates and adults. Immunohorizons 5: 512-522 (2021) [PubMed]
  7. Miljkovic D, S Stanisavljevic, IJ Jensen, TS Griffith, and VP Badovinac. Sepsis and multiple sclerosis: causative links and outcomes. Immunol Lett 238: 40-46 (2021) [PubMed]
  8. Moioffer SJ*, DB Danahy*, S van de Wall, IJ Jensen, FV Sjaastad, SM Anthony,  JT Harty, TS Griffith, and VP Badovinac. Severity of sepsis determines the degree of impairment observed in circulatory and tissue-resident memory CD8 T cell populations. J Immunol 207: 1871-1881 (2021) [PubMed]
  9. Jensen IJ*, SN Jensen*, PW McGonagill, TS Griffith, AK Mangalam*, and VP Badovinac*. Autoimmunity increases susceptibility to and mortality from sepsis. Immunohorizons 5: 844-854 (2021) 
  10. Jensen IJ, L Xiang, PW McGonagill, Q Shan, MG Fosdick, MM Tremblay, JCD Houtman, HH Xue, TS Griffith, W Peng, and VP Badovinac. Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells. eLife in press (2021) [PubMed]
  11. Lefebvre MN, FA Surette, SM Anthony, R Vijay, IJ Jensen, LL Pewe, LS Hancox, N Van Braeckel-Budimir, S Van de Wall, SL Urban, MR Mix, SP Kurup, VP Badovinac, NS Butler, and JT Harty. Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria. Cell Rep 37: 109956 (2021)

2020

  1. Danahy DB, RB Berton, and VP Badovinac. Cutting Edge: Anti-tumor immunity by pathogen-specific CD8 T cells in the absence of cognate antigen recognition. J Immunol 204: 1431-1435 (2020) [PubMed]
  2. Jensen IJ, PW McGonagill, MN Lefebvre, TS Griffith, JT Harty, and VP Badovinac.  Worry and FRET: ROS production leads to fluorochrome tandem degradation annd impairs interpretation of flow cytometric results.  Immunity 52: 419-421 (2020) [PubMed]
  3. Martin MD, R Sompallae, CS Winborn, JT Harty, and VP Badovinac. Diverse CD8 T cell responses to viral infection revealed by the Collaborative Cross. Cell Rep 31: 107508  (2020) [PubMed]
  4. Shan Q, S Hu, X Chen, DB Danahy, VP Badovinac, C Zhang, and HH Xue. Ectopic Tcf1 expression instills a stem-like program in exhausted CD8 T cells to enhance viral and tumor immunity. Cell Mol Immunol doi: 10.1038/s41423-020-0436-5 (2020)
  5. Hamilton SE, VP Badovinac, LK Beura, M Pierson, SC Jameson, D Masopust, and TS Griffith. New insights into the immune system using dirty mice.  J Immunol 205: 3-11 (2020) [PubMed]
  6. Urban SL, IJ Jensen, Q Shan, LL Pewe, HH Xue, VP Badovinac, and JT Harty.  Peripherally induced brain tissue-resident memory CD8 T cells mediate protection against CNS infection.  Nat Immunol 8: 938-949 (2020) [PubMed]
  7. Martin MD, VP Badovinac, and TS Griffith. CD4 T cell responses and the sepsis-induced immunoparalyses state.  Front Immunol 11: 1364 (2020) [PubMed]
  8. Sjaastad FV, TA Kucaba, T Dileepan, W Swanson, C Dali, J Cabrera-Perez, KA Murphy, VP Badovinac, and TS Griffith. Polymicrobial sepsis impairs antigen-specific memory CD4 T cell-mediated immunity.  Front Immunol 12: 1786 (2020) [PubMed]
  9. Sjaastad FV, IJ Jensen, RR Berton, VP Badovinac, and TS Griffith. Inducing experimental polymicrobial sepsis by cecal ligation and puncture. Curr Protoc Immunol 131: e110 (2020) [PubMed]
  10. Jensen IJ, SN Jensen, FV Sjaastad, KN Gibson-Corley, T Dileepan, TS Griffith, AK Mangalam, and VP Badovinac. Sepsis impedes EAE disease development and diminishes autoantigen-specific CD4 T cells. eLife 9: e55800 (2020) [PubMed]

2019

  1. Danahy DB,  IJ Jensen,  TS Griffith, VP Badovinac. Cutting Edge: Polymicrobial Sepsis Has the Capacity to Reinvigorate Tumor-Infiltrating CD8 T Cells and Prolong Host Survival. J Immunol 202: 2843 (2019) [PubMed]
  2. Espinosa-Cotton M, SN Rodman Iii S, KA Ross, IJ Jensen, K Sangodeyi-Miller, AJ McLaren, RA Dahl, KN Gibson-Corley KN, AT Koch, YX Fu, VP Badovinac, D Laux, B Narasimhan, AL Simons . Interleukin-1 alpha increases anti-tumor efficacy of cetuximab in head and neck squamous cell carcinoma. J Immunother Cancer 7:79 (2019) [PubMed]
  3. Danahy DB, SP Kurup, CS Winborn, IJ Jensen, JT Harty, TS Griffith, VP Badovinac. Sepsis-Induced State of Immunoparalysis Is Defined by Diminished CD8 T Cell-Mediated Antitumor Immunity. J Immunol. Jun 12. pii: ji1900435. doi: 10.4049/jimmunol.1900435. (2019) [PubMed]
  4. Martin MD, IJ Jensen, AS Ishizuka, M Lefebvre, Q Shan, HH Xue, JT Harty, RA Seder, VP Badovinac. Bystander responses impact accurate detection of murine and human antigen-specific CD8 T cells. J Clin Invest. Jun 20; 130. pii: 124443. doi: 10.1172/JCI124443. (2019) [PubMed]
  5. Espinosa-Cotton M, EJ Fertig, LP Stabile, AG Davis, JE Bauman, S Schmitz, KN Gibson-Corley, Y Cheng, IJ Jensen, VP Badovinac, D Laux, and AL Simons. A preliminary analysis of interleukin-1 ligands as potential predictive biomarkers of response to cetuximab.  Biomark Res 7: 14 (2019) [PubMed]
  6. Huggins MA, FV Sjaastad, M Pierson, TA Kucaba, W Swanson, C Staley, AR Weingarden, IJ Jensen, DB Danahy, VP Badovinac, SC Jameson, V Vezys, D Masopust, A Khortus, TS Griffith, and SE Hamilton. Microbial exposure enhances immunity to pathogens recognized by TLR2 but increases susceptibility to cytokine storm via TLR4 sensitization. Cell Rep 28: 1729-1743 (2018) (2019) [PubMed]

2018

  1. Li F, Z Zeng, S Xing, JA Gullicksrud, Q Shan, J Choi, VP Badovinac, S Crotty, W Peng, HH Xue. Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun 9: 5452 (2018)  [PubMed]
  2. Martin MD, VP Badovinac. Defining Memory CD8 T Cell. Front Immunol 9:2692 (2018) [PubMed]
  3. Jensen IJ, CS Winborn, MG Fosdick, P Shao, MM Tremblay, Q Shan, SK Tripathy, CM Snyder, HH Xue, TS Griffith, JC Houtman, VP Badovinac. Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections. PLoS Pathog 14: e1007405 (2018) [PubMed]
  4. Sjaastad FV, SA Condotta, JA Kotov, KA Pape, C Dail, DB Danahy, TA Kucaba, LT Tygrett, KA Murphy, J Cabrera-Perez, TJ Waldschmidt, VP Badovinac, TS Griffith. Polymicrobial Sepsis Chronic Immunoparalysis Is Defined by Diminished Ag-Specific T Cell-Dependent B Cell Responses. Front Immunol 9:2532 (2018) [PubMed]
  5. Jensen IJ, FV Sjaastad, TS Griffith, VP Badovinac. Sepsis-Induced T Cell Immunoparalysis: The Ins and Outs of Impaired T Cell Immunity. J Immunol 200: 1543-1553. (2018) [PubMed]
  6. Van Braeckel-Budimir N, SM Varga, VP Badovinac, JT Harty. Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity. Cell Rep 24:13 3374-3374. (2018). [PubMed]

2017

  1. Martin MD, DB Danahy, SM Hartwig, JT Harty, VP Badovinac. Revealing the Complexity in CD8 T Cell Responses to Infection in Inbred C57B/6 versus Outbred Swiss Mice. Front Immunol 8:1527 (2017) [PubMed]
  2. Danahy DB, SM Anthony, IJ Jensen, SM Hartwig, Q Shan, HH Xue, JT Harty, TS Griffith, VP Badovinac. Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells. PLoS Pathog 13: e1006569 (2017) [PubMed]
  3. Gullicksrud JA, F Li, S Xing, Z Zeng, W Peng, VP Badovinac, JT Harty, HH Xue. Differential Requirements for Tcf1 Long Isoforms in CD8+ and CD4+ T Cell Responses to Acute Viral Infection. J Immunol 199: 911-919. (2017) [PubMed]
  4.  Martin MD, Q Shan, HH Xue, VP Badovinac. Time and Antigen-Stimulation History Influence Memory CD8 T Cell Bystander Responses. Front Immunol 8: 634 (2017) [PubMed]
  5.  Shan Q, Z Zeng, S Xing, F Li, SM Hartwig, JA Gullicksrud, SP Kurup, N Van Braeckel-Budimir, Y Su, MD Martin, SM Varga, I Taniuchi, JT Harty, W Peng, VP Badovinac, HH Xue. The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol 18: 931-939. (2017) [PubMed]
  6. Van Braeckel-Budimir N, MD Martin, SM Hartwig, KL Legge, VP Badovinac, JT Harty. Antigen Exposure History Defines CD8 T Cell Dynamics and Protection during Localized Pulmonary Infections. Front Immunol 8: 40 (2017) [PubMed]
  7. Cabrera-Perez J, VP Badovinac, TS Griffith. Enteric immunity, the gut microbiome, and sepsis: Rethinking the germ theory of disease. Exp Biol Med 242: 127-139. (2017) [Pubmed]

2016

  1. Martin MD, and VP Badovinac. Sifting through CD8 T cell memory. Immunity 45: 1184-1186 (2016) [PubMed] 
  2. He B, S Xing, C Chen, P Gao, L Teng, Q Shan, JA Gullicksrud, MD Martin, S Yu, JT Harty, VP Badovinac, K Tan, and HH Xue.  CD8 T cells utilize highly dynamic enhancer repertoires and regulatory circuitry in response to infections. Immunity 45: 1341-1354 (2016) [PubMed]
  3. Strother RK, DB Danahy, DI Kotov, TA Kucaba, ZR Zacharias, TS Griffith, KL Legge, and VP Badovinac.  Polymicrobial sepsis diminishes dendritic cell numbers and function directly contributing to impaired primary CD8 T cell responses in vivo. J Immunol 197: 4301-4311 (2016) [PubMed]
  4. Janowski AM, OR Colegio, EE Hornick, JM McNiff, MD Martin, VP Badovinac, LA Norian, W Zhang, SL Cassel, and FS Sutterwala. NLRC4 suppresses melanoma tumor progression independently of Inflammasome activation. J Clin Invest 126: 3917-3928 (2016) [PubMed]
  5. Danahy DB, RK Strother, VP Badovinac, and TS Griffith. Clinical and experimental sepsis impair T cell-mediated immunity. Crit Rev Immunol 36: 57-74 (2016) [PubMed]
  6. Cabrera-Perez J, JC Babcock, T Dileepan, KA Murphy, TA Kucaba, VP Badovinac, and TS Griffith. Gut microbial membership modulates CD4 T cell reconstitution and function after sepsis. J  Immunol  197: 1692-1698 (2016) [PubMed]

2015

  1. Martin MD, and VP Badovinac. Antigen-dependent and –independent contributions to primary memory CD8 T cell activation and protection following infection. Sci Rep 5: 18022 (2015) [PubMed]
  2. Martin MD, MT Kim, Q Shan, R Sompallaie, HH Xue, JT Harty, and VP Badovinac. Phenotypic and functional alterations in circulating memory CD8 T cells with time after primary infection. PLoS Pathog 11: e1005219 (2015) [PubMed]
  3. Khan SH, MD Martin, GR Starbeck-Miller, HH Xue, JT Harty, and VP Badovinac. The timing of stimulation and IL-2 signaling regulate secondary CD8 T cell responses. PLoS Pathog 11: e1005199 (2015) [PubMed]
  4. Kim MT, MJ Richer, BP Gross, LA Norian, VP Badovinac, and JT Harty.  Enhancing dendritic cell-based immunotherapy with IL-2/mAb complexes for control of established tumors.  J Immunol 195: 4537-4544 (2015) [PubMed]
  5. Condotta SA, SH Khan, D Rai, TS Griffith, and VP Badovinac. Poly-microbial sepsis increases susceptibility to chronic viral infection and exacerbates CD8 T cell exhaustion. J Immunol 195: 116-125 (2015) [PubMed]
  6. Khan SH, and VP Badovinac. Listeria monocytogenes: a model pathogen to study antigen-specific memory CD8 T cell responses. Semin Immunopathol 37: 301-310 (2015) [PubMed]
  7. Cabrera-Perez J, SA Condotta, BR James, SW Kashem, EL Brincks, D Rai, TA Kucaba, VP Badovinac, and TS Griffith.  Alterations in Ag-specific naïve CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge. J Immunol 194: 1609-1620 (2015) [PubMed]

2014

  1. Khan SH, EA Hemann, KL Legge, LA Norian, and VP Badovinac. Diet-induced obesity does not impact the maintenance of memory CD8 T cells. J Immunol 193: 5873-5882 (2014) [PubMed]
  2. Rai D, MD Martin, and VP Badovinac. The longevity of memory CD8 T cell responses after repetitive antigen-stimulations. J Immunol 192: 5652-5659 (2014) [PubMed]
  3. Duong S, SA Condotta, D Rai, MD Martin, TS Griffith, and VP Badovinac.  Poly-microbial sepsis alters Ag-dependent and –independent memory CD8 T cell functions. J Immunol 192, 3618-3625 (2014) [PubMed]
  4. ​Martin MD, and VP Badovinac. Influence of time and number of antigen encounters on memory CD8 T cell development. Immunol Res 59: 35-44 (2014) [PubMed]
  5. Starbeck-Miller GR, VP Badovinac, and JT Harty.  Cutting Edge: Expression of FcgRIIB tempers memory CD8 T cell function in vivo. J Immunol 192: 35-39 (2014) [PubMed]
  6. Cabrera-Perez J, SA Condotta, VP Badovinac, and TS Griffith. The impact of sepsis on CD4 T cell immunity. J Leuk Biol 96: 767-777 (2014) [PubMed]
  7. Markwart R, SA Condotta, RP Requardt, F Borken, K Schubert, C Weigel, M Bauer, TS Griffith, M Forster, FM Brunkhorst, VP Badovinac, and I Rubio. Immunosuppression after sepsis: systemic inflammation and sepsis induce a loss of naïve T-cells but no enduring cell-autonomous defects in T-cell function. PLoS One 9: e115094 (2014) [PubMed]

Complete Publication List at PubMed