About The Lab
Our long-term interest lies in elucidating the mechanisms that govern CD8 T cell responses after infection and/or immunization. We are interested in exploring the pathways that are involved in Ag-specific CD8 T cell homeostasis in vivo and exploring how the manipulation of these pathways can be used to facilitate the generation and maintenance of productive memory CD8 T cell responses in health and disease.
We are also investigating the sepsis-induced state of immunoparalysis and exploring treatments to restore/improve immunity in sepsis survivors.
The Badovinac lab is currently seeking highly skilled Graduate Students and Postdoctoral Scholars to conduct cutting-edge research on T cell immunity after various types of infections and/or immunizations. Sepsis centered research based on experimental mouse models and human patients samples is priority.
Please direct inquires directly to vladimir-badovinac@uiowa.edu
New publication from Mohammad Heidarian
Sublethal whole-body irradiation induces permanent loss and dysfunction in pathogen-specific circulating memory CD8 T cell populations - PNAS 120: e2302785120 [please see the full text]
News
- Roger's paper establishing multi-infection experimental model (SPExperienced mice)
- Welcome to the lab Mohammad and Shravan!
- Isaac's eLife publications describing T cell responses/functionality during sepsis-induced immunoparalyses phase: Sepsis impedes EAE disease development and diminishes autoantigen-specific naïve CD4 T cells; and Sepsis leads to lasting changes in phenotype and function of memory CD8 T cells.
- New collaborative papers: Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria; and Tcf1 preprograms glycolysis mobilization in central memory CD8 T cells in recall response.
- Steve Moioffer defends Thesis!
- New Appointment
- Isaac Jensen defends Thesis!
- New Appointment
- Welcome to the lab Elvia!
- New letter: Worry and FRET: ROS production leads to fluorochrome degradation and impairs interpretation of flow cytometric results
- New collaborative paper: Peripherally induced brain tissue-resident memory CD8 T cells mediate protection against CNS infection
- New paper: Bystander responses impact accurate detection of murine and human antigen-specific CD8 T cells
- New collaborative paper: Microbial Exposure Enhances Immunity to Pathogens Recognized by TLR2 but Increases Susceptibility to Cytokine Storm through TLR4 Sensitization.
- Derek Danahy defends Thesis!
- Newest lab member, Roger Berton. Welcome to the lab!
- New review: Defining Memory CD8 T Cell
- New review: Sepsis induced T cell immunoparalysis: the ins and outs of impaired T cell immunity
- New paper: Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections
- New collaborative paper: Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity