Our long-term interest lies in elucidating the mechanisms that govern CD8 T cell responses after infection and/or immunization. We are interested in exploring the pathways that are involved in Ag-specific CD8 T cell homeostasis in vivo and exploring how the manipulation of these pathways can be used to facilitate the generation and maintenance of productive memory CD8 T cell responses in health and disease.
We are also investigating the sepsis-induced state of immunoparalysis and exploring treatments to restore/improve immunity in sepsis survivors.
New publication from Derek Danahy
- Cutting Edge: Polymicrobial Sepsis Has the Capacity to Reinvigorate Tumor-Infiltrating CD8 T Cells and Prolong Host Survival. See full text.
- Derek Danahy defends Thesis!
- Newest lab member, Roger Berton. Welcome to the lab!
- New paper: Defining Memory CD8 T Cell
- New paper: Sepsis induced T cell immunoparalysis: the ins and outs of impaired T cell immunity
- New paper: Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections
- New collaborative paper: Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8+ T Cells and Heterosubtypic Immunity