Badovinac Lab Photo 2025 – Mohammad, Debbie, Vladimir, Lizz, Andreas, Mahil and Shravan (As usual, Pat's MIA—though this time, we didn’t even bother pretending we’d try to get him here)
About the Lab
Our long-term interest lies in elucidating the mechanisms that govern CD8 T cell responses after infection and/or immunization. We are interested in exploring the pathways that are involved in Ag-specific CD8 T cell homeostasis in vivo and exploring how the manipulation of these pathways can be used to facilitate the generation and maintenance of productive memory CD8 T cell responses in health and disease.
We are also investigating the sepsis-induced state of immunoparalysis and exploring treatments to restore/improve immunity in sepsis survivors.
Vladimir P. Badovinac, PhD
New publications from Mohammad and Shravan
Delineating the short- and long-term impact of ionizing radiation on antigen-inexperienced CD8 + T cell subsets. JCI Insight 10: e194201 (2025)
and
Whole-body irradiation causes long-term impairments in the maintenance and function of naïve CD4 T cells specific for self- and non-self antigens. J Immunol in press (2026)
News
- Shravan defends thesis.
- New collaborative publication - Peripheral vaccination-induced brain-resident memory CD8 T cells durably protect mice against intracranial malignancy. J Clin Invest 136: e197812 (2026) [PubMed]
- New publication by Mohammad - Delineating the short- and long-term impact of ionizing radiation on antigen-inexperienced CD8 + T cell subsets. JCI Insight 10: e194201 (2025) [PubMed]
- New collaborative publication - Physiological microbial exposure normalizes memory T cell surveillance of the brain and modifies host seizure outcomes. Nat Immunol 26: 1087-1098 (2025) [PubMed]
- Welcome to the lab Andreas
- Lizz defends thesis. Manuscript describing her thesis - Escue EA et al - The ability of memory CD8 T cell subsets to numerically and functionally recover following whole body irradiation is influenced by their history of cognate antigen exposures. J Immunol 214: 2617 (2025) [PubMed]
- New collaborative publication - Repetitive antigen stimulation in the periphery dictates the composition and recall responses of brain-resident memory CD8 T cells. Cell Rep 44: 115247(2025) (PubMed)
- New comprehensive review by Mahil - Functional immunophenotyping precision therapies in sepsis. Shock 63: 189-201 (2025) (PubMed)
- Roger Berton defends thesis. New manuscript as well - Sepsis leads to lasting changes in phenotype and function of naïve CD8 T cells. PLoS Pathog 19: e1011720 (2023) (PubMed)
- Few interesting publications by Elvia - The calm after the storm: Implications of sepsis immunoparalyses on host immunity. J Immunol 211: 711-719 (2023) (Pubmed) & Defining parameters that modulate susceptibility and protection to respiratory murine coronavirus MHV1 infection. J Immunol 212: 563-575 (2024) (PubMed)
New publications - Recovery, maintenance, and function of memory T cell subsets following radiation exposure; PNAS 120: e2302785120 (2023)/ J Exp Med 221: e20231144 (2024)