Deepa Rai, MS

Research Assistant 2010- 2015

Training

BS, Cell and Molecular Biology, Winona State University, 2006
MS, Pathology, University of Iowa, 2010

Research

My research focuses on how repeated antigenic stimulations influence the generation and longevity of memory CD8 T cell population and whether/how an individual host maintains the improved and protective immune responses to the re-infection.

Publications

  1. Condotta SA, Khan SH, Rai D, Griffith TS, Badovinac VP. Polymicrobial sepsis increases susceptibility to chronic viral infection and exacerbates CD8+ T cell exhaustion. J Immunol 195: 116-125 (2015).
     
  2. Cabrera-Perez J, Condotta SA, James BR, Kashem SW, Brincks EL, Rai D, Kucaba TA, Badovinac VP, Griffith TS. Alterations in antigen-specific naïve CD4 T cell precursors after sepsis impairs their responsiveness to pathogen challenge. J Immunol 194: 1609-1620 (2015).
     
  3. Rai D, Martin MD, Badovinac VP. The longevity of memory CD8 T cell responses after repetitive antigen stimulations. J Immunol 192: 5652-5659 (2014).
     
  4. Duong S, Condotta SA, Rai D, Martin MD, Griffith TS, Badovinac VP. Polymicrobial sepsis alters antigen-dependent and –independent memory CD8 T cell functions. J Immunol 192: 3618-3625 (2014).
     
  5. Condotta SA, Rai D, James BR, Griffith TS, Badovinac VP. Sustained and Incomplete Recovery of Naive CD8+ T Cell Precursors after Sepsis Contributes to Impaired CD8+ T Cell Responses to Infection. J Immunol 190: 1991-2000 (2013).
     
  6. Nolz JC, Rai D, Badovinac VP, Harty JT. Division-linked generation of ‘death-intermediates’ regulates the numerical stability of memory CD8 T cells. Proc Natl Acad Sci 109: 6199-6204 (2012).
     
  7. Gurung P, Rai D, Condotta SA, Babcock JC, Badovinac VP, Griffith TS. Immune Unresponsivenss to Secondary heterologous bacterial Infection after Sepsis Induction is Trail Dependent. J Immunol 187: 2148-2154 (2011).
     
  8. Wirth TC, Xue HH, Rai D, Sabel JL, Bair T, Harty JT, Badovinac VP. Repetitive Antigen Stimulations Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8 T Cell Differentiation. Immunity 33: 128-140 (2010).
     
  9. Rai D, Pham NL, Harty JT, Badovinac VP. Tracking the total CD8 T Cell Response to Infection Reveals stantial Discordance in Magnitude and Kinetics between Inbred and Outbred Hosts. J Immunol 183: 7672-7681 (2009).
Deepa Rai