Lab members and Dr. Badovinac posing on the Medical Laboratories with their arms outstretched and they're all wearing red plaid flannel shirts
Badovinac Lab Photo 2023 – Mahil, Lizz, Roger, Mohammad, Vladimir, Debbie, Shravan, and Elvia (Pat is missing, as always)

About the Lab

Our long-term interest lies in elucidating the mechanisms that govern CD8 T cell responses after infection and/or immunization. We are interested in exploring the pathways that are involved in Ag-specific CD8 T cell homeostasis in vivo and exploring how the manipulation of these pathways can be used to facilitate the generation and maintenance of productive memory CD8 T cell responses in health and disease.

We are also investigating the sepsis-induced state of immunoparalysis and exploring treatments to restore/improve immunity in sepsis survivors.

Research

The Badovinac lab is currently seeking highly skilled Graduate Students and Postdoctoral Scholars to conduct cutting-edge research on T cell immunity after various types of infections and/or immunizations. Sepsis centered research based on experimental mouse models and human patients samples is priority.

Please direct inquires directly to vladimir-badovinac@uiowa.edu

Dr. Badovinac

Vladimir P. Badovinac, PhD

Pathology Endowed Professor in Infection & Immunity Research
vladimir-badovinac@uiowa.edu
319-384-2929
Faculty Profile
Extracurricular interests: Riding his bike around town....... and only occasionally crashing

New publication from Roger, Shravan & Mohammad 

Accurate enumeration of pathogen-specific and virtual memory CD8 T cells after infection - 

J Immunol  [please see the full text]

News

  • Welcome to the lab Andreas
  • Lizz defends thesis
  • New collaborative publication - Repetitive antigen stimulation in the periphery dictates the composition and recall responses of brain-resident memory CD8 T cells. Cell Rep 44: 115247(2025) (PubMed)
  • New comprehensive review by Mahil - Functional immunophenotyping precision therapies in sepsis. Shock 63: 189-201 (2025) (PubMed)
  • Roger Berton defends thesis.  New manuscript as well - Sepsis leads to lasting changes in phenotype and function of naïve CD8 T cells. PLoS Pathog 19: e1011720 (2023) (PubMed)
  • Few interesting publications by Elvia - The calm after the storm:  Implications of sepsis immunoparalyses on host immunity. J Immunol 211: 711-719 (2023) (Pubmed) & Defining parameters that modulate susceptibility and protection to respiratory murine coronavirus MHV1 infection. J Immunol 212: 563-575 (2024) (PubMed)
  • New publications - Recovery, maintenance, and function of memory T cell subsets following radiation exposure; PNAS 120: e2302785120 (2023)/ J Exp Med 221: e20231144 (2024)
  • Welcome Mahil and Lizz

  • Roger's paper establishing multi-infection experimental model (SPExperienced mice)